Rams vs. Bills odds, line, spread, predictions: 2022 NFL Kickoff Game picks from computer model on 138-97 run

Starting the season on a winning note has been a regular occurrence for the Los Angeles Rams under head coach Sean McVay. Since he took over as coach in 2017, Los Angeles has won its opener and gone one to finish with a winning record every year. It has made four playoff appearances and two trips to the Super Bowl with McVay at the helm, winning the championship last season. The Rams will try to continue their streak in openers under McVay when they host the Buffalo Bills in the 2022 NFL Kickoff Game on Thursday.

Kickoff from SoFi Stadium is set for 8:20 p.m. ET. Buffalo is a 2.5-point favorite in the latest Bills vs. Rams odds from Caesars Sportsbook, while the over/under for total points scored is 53. Before making any Rams vs. Bills picks, make sure to check out the expert NFL predictions and betting advice from SportsLine’s proven computer model

The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception. The model enters the 2022 NFL season on an incredible 138-97 run on top-rated NFL picks that dates back to the 2017 season. Amazingly, it hasn’t missed a top-rated pick since Week 15 last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has simulated Bills vs. Rams in the NFL Kickoff Game 2022 10,000 times and just revealed its NFL expert picks and predictions. You can head to SportsLine now to see its picks. Here are several NFL odds and betting trends for Rams vs. Bills:

  • Bills vs. Rams spread: Buffalo -2.5
  • Bills vs. Rams over/under: 53 points
  • Bills vs. Rams money line: Buffalo -135, Los Angeles +115
  • BUF: Bills scored at least 31 points in 11 of their 19 games last season, including playoffs
  • LAR: Rams have lost their last three home games against Buffalo
  • Bills vs. Rams picks: See picks at SportsLine

Featured Game | Los Angeles Rams vs. Buffalo Bills

Why the Bills can cover

Buffalo is 8-5 in the all-time series against the Rams, but has been dominant of late, winning seven of the last nine meetings. The Bills posted a 35-32 home victory in the most recent matchup in 2020 and a 30-19 triumph in their last visit to Los Angeles four years earlier. Buffalo has won three straight road contests against the Rams, although two were when the franchise was located in St. Louis.

Josh Allen is coming off a campaign during which he terrorized opposing defenses with both his arm and legs. The 26-year-old, who was the seventh overall pick in the 2018 NFL Draft, became the first player in league history to throw for at least 4,000 yards (4,407) and run for 750 or more (763) in a season. Allen had 36 touchdown passes and ran for six scores during the regular season while adding a whopping nine TD tosses in only two playoff games.

Why the Rams can cover

Los Angeles has had its offense in high gear during McVay’s tenure. The team has scored at least 20 points in each of its five season-opening wins under McVay and 30 or more on four occasions. Matthew Stafford threw three touchdown passes in the Rams’ 34-14 triumph over Chicago in Week 1 last year, the first of nine regular-season contests in which he made at least a trio of scoring tosses.

Stafford finished third in the NFL with 4,886 yards through the air in 2021 and second with 41 TD passes. The 34-year-old added 1,198 yards during Los Angeles’ run to the Super Bowl championship, the second-most in one postseason in league history (Eli Manning, 1,219 in 2011). Stafford is looking to become the seventh player to record 10 4,000-yard seasons in his career.

How to make Rams vs. Bills picks

SportsLine’s model is leaning Under on the total, projecting the teams to combine for 48 points. It also says one side of the spread cashes in well over 50% of simulations. Head to SportsLine to see its NFL picks

So who wins Bills vs. Rams in the NFL Kickoff Game 2022? And which side of the spread cashes well over 50% of the time? Visit SportsLine now to see the Bills vs. Rams picks, all from the model that has returned over $7,500 on top-rated NFL picks, and find out.


Leave a Reply